Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature viral particles. Anti-FLE antibodies are broadly cross-reactive but poorly...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Rouvinski, Alexander, Dejnirattisai, Wanwisa, Guardado-Calvo, Pablo, Vaney, Marie-Christine, Sharma, Arvind, Duquerroy, Stéphane, Supasa, Piyada, Wongwiwat, Wiyada, Haouz, Ahmed, Barba-Spaeth, Giovanna, Mongkolsapaya, Juthathip, Rey, Félix A., Screaton, Gavin R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457521/
https://ncbi.nlm.nih.gov/pubmed/28534525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15411
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