A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection

Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes—one to precursor membrane protein and one to the fusion loop epitope on envelope (E) protein—are recognized by cross-reactive antibodies(1–3) that are not only poorly n...

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Udgivet i:Nat Immunol
Main Authors: Slon-Campos, Jose Luis, Dejnirattisai, Wanwisa, Jagger, Brett W., López-Camacho, César, Wongwiwat, Wiyada, Durnell, Lorellin A., Winkler, Emma S., Chen, Rita E., Reyes-Sandoval, Arturo, Rey, Felix A., Diamond, Michael S., Mongkolsapaya, Juthathip, Screaton, Gavin R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839414/
https://ncbi.nlm.nih.gov/pubmed/31477918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0477-z
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