Anti-Dengue E-dimer epitope human antibodies have therapeutic activity against Zika virus infection

The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive DENV antibodies can enhance ZIKV infection in mice, those recognizing the E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic ac...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Fernandez, Estefania, Dejnirattisai, Wanwisa, Cao, Bin, Scheaffer, Suzanne M., Supasa, Piyada, Wongwiwat, Wiyada, Esakky, Prabagaran, Drury, Andrea, Mongkolsapaya, Juthathip, Moley, Kelle H., Mysorekar, Indira U., Screaton, Gavin R., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679314/
https://ncbi.nlm.nih.gov/pubmed/28945244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3849
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