Estimating TP53 Mutation Carrier Probability in Families with Li-Fraumeni Syndrome Using LFSPRO

BACKGROUND: Li-Fraumeni syndrome (LFS) is associated with germline TP53 mutations and a very high lifetime cancer risk. Algorithms that assess a patient's risk of inherited cancer predisposition are often used in clinical counseling. The existing LFS criteria have limitations, suggesting the ne...

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Publicado en:Cancer Epidemiol Biomarkers Prev
Autores principales: Peng, Gang, Bojadzieva, Jasmina, Ballinger, Mandy L., Li, Jialu, Blackford, Amanda L., Mai, Phuong L., Savage, Sharon A., Thomas, David M., Strong, Louise C., Wang, Wenyi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457344/
https://ncbi.nlm.nih.gov/pubmed/28137790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-16-0695
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