Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: a Phase II National Cancer Institute/Stand Up to Cancer Study

PURPOSE: In breast cancer models, combination epigenetic therapy with a DNA methyltransferase inhibitor and a histone deacetylase inhibitor led to re-expression of genes encoding important therapeutic targets including the estrogen receptor (ER). We conducted a multicenter phase II study of 5-azacit...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Connolly, Roisin M, Li, Huili, Jankowitz, Rachel C, Zhang, Zhe, Rudek, Michelle A, Jeter, Stacie C, Slater, Shannon A, Powers, Penny, Wolff, Antonio C, Fetting, John H, Brufsky, Adam, Piekarz, Richard, Ahuja, Nita, Laird, Peter W, Shen, Hui, Weisenberger, Daniel J, Cope, Leslie, Herman, James G, Somlo, George, Garcia, Agustin A, Jones, Peter A, Baylin, Stephen B, Davidson, Nancy E, Zahnow, Cynthia A, Stearns, Vered
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457329/
https://ncbi.nlm.nih.gov/pubmed/27979916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1729
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