Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand Up 2 cancer study

PURPOSE: Therapy with demethylating agent 5-azacitidine and histone deacetylase inhibitor entinostat shows synergistic re-expression of tumor-suppressor genes and growth inhibition in colorectal (CRC) cell lines and in vivo studies. EXPERIMENTAL DESIGN: We conducted a phase II, multi-institutional s...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Azad, Nilofer S., el-Khoueiry, Anthony, Yin, Jun, Oberg, Ann L., Flynn, Patrick, Adkins, Douglas, Sharma, Anup, Weisenberger, Daniel J., Brown, Thomas, Medvari, Prakriti, Jones, Peter A., Easwaran, Hariharan, Kamel, Ihab, Bahary, Nathan, Kim, George, Picus, Joel, Pitot, Henry C., Erlichman, Charles, Donehower, Ross, Shen, Hui, Laird, Peter W., Piekarz, Richard, Baylin, Stephen, Ahuja, Nita
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471058/
https://ncbi.nlm.nih.gov/pubmed/28186961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15108
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