Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand Up 2 cancer study

PURPOSE: Therapy with demethylating agent 5-azacitidine and histone deacetylase inhibitor entinostat shows synergistic re-expression of tumor-suppressor genes and growth inhibition in colorectal (CRC) cell lines and in vivo studies. EXPERIMENTAL DESIGN: We conducted a phase II, multi-institutional s...

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Udgivet i:Oncotarget
Main Authors: Azad, Nilofer S., el-Khoueiry, Anthony, Yin, Jun, Oberg, Ann L., Flynn, Patrick, Adkins, Douglas, Sharma, Anup, Weisenberger, Daniel J., Brown, Thomas, Medvari, Prakriti, Jones, Peter A., Easwaran, Hariharan, Kamel, Ihab, Bahary, Nathan, Kim, George, Picus, Joel, Pitot, Henry C., Erlichman, Charles, Donehower, Ross, Shen, Hui, Laird, Peter W., Piekarz, Richard, Baylin, Stephen, Ahuja, Nita
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Clinical Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471058/
https://ncbi.nlm.nih.gov/pubmed/28186961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15108
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