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Reduced levels of Cacna1c attenuate mesolimbic dopamine system function

Genetic variation in CACNA1C, which codes for the L-type calcium channel (LTCC) Ca(v)1.2, is associated with clinical diagnoses of bipolar disorder, depression, and schizophrenia. Dysregulation of the mesolimbic dopamine (DA) system is linked to these syndromes and LTCCs are required for normal DAer...

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Publicado en:Genes Brain Behav
Autores principales: Terrillion, Chantelle E., Dao, David T., Cachope, Roger, Lobo, Mary Kay, Puche, Adam C., Cheer, Joseph F., Gould, Todd D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457318/
https://ncbi.nlm.nih.gov/pubmed/28186690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gbb.12371
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