mtDNA mutations increase tumorigenicity in prostate cancer

Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11–12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (me...

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Detalles Bibliográficos
Autores principales: Petros, John A., Baumann, Amanda K., Ruiz-Pesini, Eduardo, Amin, Mahul B., Sun, Carrie Qi, Hall, John, Lim, SoDug, Issa, Muta M., Flanders, W. Dana, Hosseini, Seyed H., Marshall, Fray F., Wallace, Douglas C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC545582/
https://ncbi.nlm.nih.gov/pubmed/15647368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408894102
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