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mtDNA mutations increase tumorigenicity in prostate cancer
Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11–12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (me...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2005
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545582/ https://ncbi.nlm.nih.gov/pubmed/15647368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408894102 |
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