mtDNA mutations increase tumorigenicity in prostate cancer

Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11–12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (me...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Petros, John A., Baumann, Amanda K., Ruiz-Pesini, Eduardo, Amin, Mahul B., Sun, Carrie Qi, Hall, John, Lim, SoDug, Issa, Muta M., Flanders, W. Dana, Hosseini, Seyed H., Marshall, Fray F., Wallace, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545582/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15647368/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408894102
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