mtDNA mutations increase tumorigenicity in prostate cancer

Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11–12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (me...

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Bibliografische gegevens
Hoofdauteurs: Petros, John A., Baumann, Amanda K., Ruiz-Pesini, Eduardo, Amin, Mahul B., Sun, Carrie Qi, Hall, John, Lim, SoDug, Issa, Muta M., Flanders, W. Dana, Hosseini, Seyed H., Marshall, Fray F., Wallace, Douglas C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545582/
https://ncbi.nlm.nih.gov/pubmed/15647368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408894102
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