Hemoglobin-Induced Endothelial Cell Permeability Is Controlled, in Part, via a Myeloid Differentiation Primary Response Gene–88–Dependent Signaling Mechanism

The release of hemoglobin (Hb) with hemolysis causes vascular dysfunction. New evidence implicates Hb-induced NF-κB and hypoxia inducible factor (HIF) activation, which may be under the control of a Toll-like receptor (TLR)–signaling pathway. Nearly all TLR-signaling pathways activate the myeloid di...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Lisk, Christina, Kominsky, Doug, Ehrentraut, Stefan, Bonaventura, Joe, Nuss, Rachelle, Hassell, Kathryn, Nozik-Grayck, Eva, Irwin, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455457/
https://ncbi.nlm.nih.gov/pubmed/23713977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0440OC
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