Llwytho...
An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase
We report on the NMR-based solution structure of the 93del d(GGGGTGGGAGGAGGGT) aptamer, a potent nanomolar inhibitor of HIV-1 integrase. This guanine-rich DNA sequence adopts an unusually stable dimeric quadruplex architecture in K(+) solution. Within each 16-nt monomer subunit, which contains one A...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
National Academy of Sciences
2005
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545538/ https://ncbi.nlm.nih.gov/pubmed/15637158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406278102 |
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