Active site restructuring regulates ligand recognition in class A penicillin-binding proteins

Bacterial cell division is a complex, multimolecular process that requires biosynthesis of new peptidoglycan by penicillin-binding proteins (PBPs) during cell wall elongation and septum formation steps. Streptococcus pneumoniae has three bifunctional (class A) PBPs that catalyze both polymerization...

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Bibliographic Details
Main Authors: Macheboeuf, Pauline, Di Guilmi, Anne Marie, Job, Viviana, Vernet, Thierry, Dideberg, Otto, Dessen, Andréa
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545533/
https://ncbi.nlm.nih.gov/pubmed/15637155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407186102
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