A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene products. In polyQ diseases, the pathology and death of affected neurons are associated with the accumulation of mutant proteins in insoluble a...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Zhang, Xiaoqian, Smith, Donna L., Meriin, Anatoli B., Engemann, Sabine, Russel, Deborah E., Roark, Margo, Washington, Shetia L., Maxwell, Michele M., Marsh, J. Lawrence, Thompson, Leslie Michels, Wanker, Erich E., Young, Anne B., Housman, David E., Bates, Gillian P., Sherman, Michael Y., Kazantsev, Aleksey G.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545525/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15642944/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408936102
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