Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides

Human leukocyte antigen (HLA)-DQ2.5 (DQA1*05/DQB1*02) is a class-II major histocompatibility complex protein associated with both type 1 diabetes and celiac disease. One unusual feature of DQ2.5 is its high class-II-associated invariant chain peptide (CLIP) content. Moreover, HLA-DQ2.5 preferentiall...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nguyen, Thanh-Binh, Jayaraman, Priya, Bergseng, Elin, Madhusudhan, M. S., Kim, Chu-Young, Sollid, Ludvig M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454103/
https://ncbi.nlm.nih.gov/pubmed/28364043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785139
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