MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo

Thyroid hormone (TH) is recognized for its role in cellular metabolism and growth and participates in homeostasis of the heart. T3 activates pro-survival pathways including Akt and mTOR. Treatment with T3 after myocardial infarction is cardioprotective and promotes elements of physiological hypertro...

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Bibliographic Details
Published in:J Mol Endocrinol
Main Authors: Wadosky, Kristine M, Berthiaume, Jessica M, Tang, Wei, Zungu, Makhosi, Portman, Michael A, Gerdes, A Martin, Willis, Monte S
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453669/
https://ncbi.nlm.nih.gov/pubmed/26862156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-15-0283
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