The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

The transcriptional regulation of peroxisome proliferator-activated receptor (PPAR) α by post-translational modification, such as ubiquitin, has not been described. We report here for the first time an ubiquitin ligase (muscle ring finger-1/MuRF1) that inhibits fatty acid oxidation by inhibiting PPA...

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Detalhes bibliográficos
Publicado no:Mol Cell Endocrinol
Main Authors: Rodríguez, Jessica E., Liao, Jie-Ying, He, Jun, Schisler, Jonathan C., Newgard, Christopher B., Drujan, Doreen, Glass, David L., Frederick, C.Brandon, Yoder, Bryan C., Lalush, David S., Patterson, Cam, Willis, Monte S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523404/
https://ncbi.nlm.nih.gov/pubmed/26116825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2015.06.008
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