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IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718
METHODS: Alanine scan of insulin receptor (IR)-B exon 11 and site-directed mutagenesis of amino acid 718 in human IR-A and IR-B were performed. Ligand affinities to wild type and mutated receptors were studied by displacement of radioactive insulin in binding assay on secreted soluble midi receptors...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5453582/ https://ncbi.nlm.nih.gov/pubmed/28570711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178885 |
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