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Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches
The Hippo signaling pathway, which is implicated in the regulation of organ size, has emerged as a potential target for the development of cancer therapeutics. YAP, TAZ (transcription co-activators) and TEAD (transcription factor) are the downstream transcriptional machinery and effectors of the pat...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5453487/ https://ncbi.nlm.nih.gov/pubmed/28570566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178381 |
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