In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s

Oprozomib is an oral proteasome inhibitor currently under investigation in patients with hematologic malignancies or solid tumors. Oprozomib elicits potent pharmacological actions by forming a covalent bond with the active site N-terminal threonine of the 20S proteasome. Oprozomib has a short half-l...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Drug Metab Dispos
Egile Nagusiak: Wang, Zhican, Fang, Ying, Teague, Juli, Wong, Hansen, Morisseau, Christophe, Hammock, Bruce D., Rock, Dan A., Wang, Zhengping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2017
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452678/
https://ncbi.nlm.nih.gov/pubmed/28428366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.075226
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