Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor

The constitutive androstane receptor (CAR) plays an important role in xenobiotic metabolism, energy homeostasis, and cell proliferation. Antagonism of the CAR represents a key strategy for studying its function and may have potential clinical applications. However, specific human CAR (hCAR) antagoni...

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Gepubliceerd in:Mol Pharmacol
Hoofdauteurs: Mackowiak, Bryan, Li, Linhao, Welch, Matthew A., Li, Daochuan, Jones, Jace W., Heyward, Scott, Kane, Maureen A., Swaan, Peter W., Wang, Hongbing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452073/
https://ncbi.nlm.nih.gov/pubmed/28442602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.108621
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