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Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077

Competitive antagonists against N-methyl-D-aspartate (NMDA) receptors have played critical roles throughout the history of neuropharmacology and basic neuroscience. There are currently numerous NMDA receptor antagonists containing a variety of chemical groups. Among those compounds, a GluN2-specific...

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Publicat a:Mol Pharmacol
Autors principals: Romero-Hernandez, Annabel, Furukawa, Hiro
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452055/
https://ncbi.nlm.nih.gov/pubmed/28468946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.107912
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