A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key roles in brain physiology and pathology. Because numerous pathologic conditions involve NMDAR overactivation, subunit-selective antagonists hold strong therapeutic potential, although clinical successes remain lim...

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Foilsithe in:Mol Pharmacol
Main Authors: Stroebel, David, Buhl, Derek L., Knafels, John D., Chanda, Pranab K., Green, Michael, Sciabola, Simone, Mony, Laetitia, Paoletti, Pierre, Pandit, Jayvardhan
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859819/
https://ncbi.nlm.nih.gov/pubmed/26912815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.103036
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