Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet production and whether enhanced platelet production contributes to enhanced atherothrombosis remains unknown. Here we found...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kraakman, Michael J., Lee, Man K.S., Al-Sharea, Annas, Dragoljevic, Dragana, Barrett, Tessa J., Montenont, Emilie, Basu, Debapriya, Heywood, Sarah, Kammoun, Helene L., Flynn, Michelle, Whillas, Alexandra, Hanssen, Nordin M.J., Febbraio, Mark A., Westein, Erik, Fisher, Edward A., Chin-Dusting, Jaye, Cooper, Mark E., Berger, Jeffrey S., Goldberg, Ira J., Nagareddy, Prabhakara R., Murphy, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451242/
https://ncbi.nlm.nih.gov/pubmed/28504650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92450
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