Apoptotic ablation of platelets reduces atherosclerosis in mice with diabetes

OBJECTIVE: People with diabetes are at a significantly higher risk of cardiovascular disease, in part, due to accelerated atherosclerosis. Diabetic subjects have increased number of platelets that are activated, more reactive, and respond sub-optimally to anti-platelet therapies. We hypothesized tha...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Lee, Man K.S., Kraakman, Michael J., Dragoljevic, Dragana, Hanssen, Nordin M.J., Flynn, Michelle C., Al-Sharea, Annas, Sreejit, Gopalkrishna, Bertuzo-Veiga, Camilla, Cooney, Olivia D., Baig, Fatima, Morriss, Elizabeth, Cooper, Mark E., Josefsson, Emma C., Kile, Benjamin T., Nagareddy, Prabhakara R., Murphy, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904582/
https://ncbi.nlm.nih.gov/pubmed/33441028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315369
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