Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation of kinase signaling via stimulation of endogenous phosphatases has received minimal attenti...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Clin Invest
मुख्य लेखकों: Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B., Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D., O’Connor, Caitlin M., Hoon, Divya, Dhawan, Neil S., Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C., Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C., Yuan, Eric, Avelar, Rita A., Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M., McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C., Sears, Rosalie C., Chen, Edward Y., Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma’ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D., Brautigan, David L., Ioannou, Yiannis A., Xu, Wenqing, Chance, Mark R., Ohlmeyer, Michael, Narla, Goutham
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2017
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451217/
https://ncbi.nlm.nih.gov/pubmed/28504649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89548
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