Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation of kinase signaling via stimulation of endogenous phosphatases has received minimal attenti...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Clin Invest
Κύριοι συγγραφείς: Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B., Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D., O’Connor, Caitlin M., Hoon, Divya, Dhawan, Neil S., Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C., Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C., Yuan, Eric, Avelar, Rita A., Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M., McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C., Sears, Rosalie C., Chen, Edward Y., Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma’ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D., Brautigan, David L., Ioannou, Yiannis A., Xu, Wenqing, Chance, Mark R., Ohlmeyer, Michael, Narla, Goutham
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2017
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451217/
https://ncbi.nlm.nih.gov/pubmed/28504649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89548
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