Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for the determination of VNT in two various matrices including rat liver microsomes (RLMs) and...

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Опубликовано в: :Chem Cent J
Главные авторы: Amer, Sawsan M., Kadi, Adnan A., Darwish, Hany W., Attwa, Mohamed W.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449356/
https://ncbi.nlm.nih.gov/pubmed/29086823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-017-0274-4
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