Liquid chromatography–tandem mass spectrometry metabolic profiling of nazartinib reveals the formation of unexpected reactive metabolites

Nazartinib (EGF816, NZB) is a promising third-generation human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This novel irreversible mutant-selective EGFR inhibitor targets EGFR containing both the resistance mutation (T790M) and the activating mutations (L858R and Del19), while...

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Udgivet i:R Soc Open Sci
Main Authors: Abdelhameed, Ali S., Attwa, Mohamed W., Kadi, Adnan A.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731747/
https://ncbi.nlm.nih.gov/pubmed/31598253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.190852
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