Combined inhibition of both p110α and p110β isoforms of phosphatidylinositol 3-kinase is required for sustained therapeutic effect in PTEN-deficient, ER+ breast cancer

PURPOSE: Determine the roles of the phosphatidylinositol 3-kinase (PI3K) isoforms p110α and p110β in PTEN-deficient, estrogen receptor α (ER)-positive breast cancer, and the therapeutic potential of isoform-selective inhibitors. EXPERIMENTAL DESIGN: Anti-estrogen-sensitive and -resistant PTEN-defici...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Hosford, Sarah R., Dillon, Lloye M., Bouley, Stephanie J., Rosati, Rachele, Yang, Wei, Chen, Vivian S., Demidenko, Eugene, Morra, Rocco P., Miller, Todd W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449270/
https://ncbi.nlm.nih.gov/pubmed/27903677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2764
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