Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

Antibody drug conjugates (ADCs) are no longer an unknown entity in the field of cancer therapy with the success of marketed ADCs like ADCETRIS and KADCYLA and numerous others advancing through clinical trials. The pursuit of novel cytotoxic payloads beyond the mictotubule inhibitors and DNA damaging...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L. Nathan, Sapra, Puja, Subramanyam, Chakrapani, O’Donnell, Christopher J., Graziani, Edmund I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448779/
https://ncbi.nlm.nih.gov/pubmed/28558059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178452
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