Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

Antibody drug conjugates (ADCs) are no longer an unknown entity in the field of cancer therapy with the success of marketed ADCs like ADCETRIS and KADCYLA and numerous others advancing through clinical trials. The pursuit of novel cytotoxic payloads beyond the mictotubule inhibitors and DNA damaging...

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Veröffentlicht in:PLoS One
Hauptverfasser: Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L. Nathan, Sapra, Puja, Subramanyam, Chakrapani, O’Donnell, Christopher J., Graziani, Edmund I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448779/
https://ncbi.nlm.nih.gov/pubmed/28558059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178452
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