Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

Antibody drug conjugates (ADCs) are no longer an unknown entity in the field of cancer therapy with the success of marketed ADCs like ADCETRIS and KADCYLA and numerous others advancing through clinical trials. The pursuit of novel cytotoxic payloads beyond the mictotubule inhibitors and DNA damaging...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L. Nathan, Sapra, Puja, Subramanyam, Chakrapani, O’Donnell, Christopher J., Graziani, Edmund I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448779/
https://ncbi.nlm.nih.gov/pubmed/28558059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178452
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados