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Phase Separation and Single-Chain Compactness of Charged Disordered Proteins Are Strongly Correlated

Liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is a major undergirding factor in the regulated formation of membraneless organelles in the cell. The phase behavior of an IDP is sensitive to its amino acid sequence. Here we apply a recent random-phase-approximation polymer...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Lin, Yi-Hsuan, Chan, Hue Sun
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448239/
https://ncbi.nlm.nih.gov/pubmed/28483149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.021
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