Ectopic protein interactions within BRD4–chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma

To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT midline carcinoma (NMC), we have identified protein interactions unique to the BRD4–NUT fusion oncoprotein compared with wild-type BRD4. Using cross-linking, affinity purification, and mass spectrometry, we ide...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Alekseyenko, Artyom A., Walsh, Erica M., Zee, Barry M., Pakozdi, Tibor, Hsi, Peter, Lemieux, Madeleine E., Dal Cin, Paola, Ince, Tan A., Kharchenko, Peter V., Kuroda, Mitzi I., French, Christopher A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448232/
https://ncbi.nlm.nih.gov/pubmed/28484033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702086114
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