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NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism

NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that typically harbors BRD4/3-NUT fusion oncoproteins that block differentiation and maintain tumor growth. In 20% of cases NUT is fused to uncharacterized non-BRD gene(s). We established a new patient-derived NMC cell l...

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Main Authors:	French, Christopher A., Rahman, Shaila, Walsh, Erica M., Kühnle, Simone, Grayson, Adlai R., Lemieux, Madeleine E., Grunfeld, Noam, Rubin, Brian P., Antonescu, Cristina R., Zhang, Songlin, Venkatramani, Rajkumar, Cin, Paola Dal, Howley, Peter M.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2014
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4125436/ https://ncbi.nlm.nih.gov/pubmed/24875858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0014
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NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism

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