MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma

NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins that block differentiation and maintain tumor growth. BRD-NUT oncoproteins contain two bromodomains whose binding to acetylated his...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Grayson, Adlai R., Walsh, Erica M., Cameron, Michael J., Godec, Jernej, Ashworth, Todd, Ambrose, Jessica M., Aserlind, Alexandra B., Wang, Hongfang, Evan, Gerard, Kluk, Michael J., Bradner, James E., Aster, Jon C., French, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942361/
https://ncbi.nlm.nih.gov/pubmed/23604113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.126
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares