MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma

NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins that block differentiation and maintain tumor growth. BRD-NUT oncoproteins contain two bromodomains whose binding to acetylated his...

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Detalhes bibliográficos
Main Authors: Grayson, Adlai R., Walsh, Erica M., Cameron, Michael J., Godec, Jernej, Ashworth, Todd, Ambrose, Jessica M., Aserlind, Alexandra B., Wang, Hongfang, Evan, Gerard, Kluk, Michael J., Bradner, James E., Aster, Jon C., French, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942361/
https://ncbi.nlm.nih.gov/pubmed/23604113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.126
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