The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most aggressive human solid malignancies known. NMC is driven by the creation of a translocation oncoprotein, BRD4-NUT, which blocks differentiation and drives growth of NMC cells. BRD4-NUT forms distinctive nuclear foci i...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Alekseyenko, Artyom A., Walsh, Erica M., Wang, Xin, Grayson, Adlai R., Hsi, Peter T., Kharchenko, Peter V., Kuroda, Mitzi I., French, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526735/
https://ncbi.nlm.nih.gov/pubmed/26220994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267583.115
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