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The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains
NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most aggressive human solid malignancies known. NMC is driven by the creation of a translocation oncoprotein, BRD4-NUT, which blocks differentiation and drives growth of NMC cells. BRD4-NUT forms distinctive nuclear foci i...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526735/ https://ncbi.nlm.nih.gov/pubmed/26220994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267583.115 |
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