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Combined HMG-COA reductase and prenylation inhibition in treatment of CCM

Cerebral cavernous malformations (CCMs) are common vascular anomalies that develop in the central nervous system and, more rarely, the retina. The lesions can cause headache, seizures, focal neurological deficits, and hemorrhagic stroke. Symptomatic lesions are treated according to their presentatio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nishimura, Sayoko, Mishra-Gorur, Ketu, Park, JinSeok, Surovtseva, Yulia V., Sebti, Said M., Levchenko, Andre, Louvi, Angeliki, Gunel, Murat
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448170/
https://ncbi.nlm.nih.gov/pubmed/28500274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702942114
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