HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival

Statins are a well-established family of drugs that lower cholesterol levels via the competitive inhibition of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). In addition, the pleiotropic anti-inflammatory effects of statins on T cells make them attractive as therapeutic drugs in...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Lacher, Sonja M, Bruttger, Julia, Kalt, Bettina, Berthelet, Jean, Rajalingam, Krishnaraj, Wörtge, Simone, Waisman, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520735/
https://ncbi.nlm.nih.gov/pubmed/28542128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.221
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