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MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis

Checkpoint kinase 1 (Chk1) is an evolutionarily conserved serine/threonine kinase that plays an important role in G(2)/M checkpoint signaling. Here, we evaluate the radiosensitizing effects of a novel selective Chk1 inhibitor MK-8776, comparing its efficacy with a first-generation Chk1 inhibitor UCN...

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Bibliografiske detaljer
Udgivet i:Transl Oncol
Main Authors: Suzuki, Motofumi, Yamamori, Tohru, Bo, Tomoki, Sakai, Yuri, Inanami, Osamu
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447387/
https://ncbi.nlm.nih.gov/pubmed/28550769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2017.04.002
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