Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation

Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation that can lead to their oncogenic transformation. Mediator(s) of cell–cell communication that brings about these pro-oncogenic pathologies has not been identified. We show here that cell-free chromatin (cfCh) r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Discov
Prif Awduron: Mittra, Indraneel, Samant, Urmila, Sharma, Suvarna, Raghuram, Gorantla V, Saha, Tannistha, Tidke, Pritishkumar, Pancholi, Namrata, Gupta, Deepika, Prasannan, Preeti, Gaikwad, Ashwini, Gardi, Nilesh, Chaubal, Rohan, Upadhyay, Pawan, Pal, Kavita, Rane, Bhagyeshri, Shaikh, Alfina, Salunkhe, Sameer, Dutt, Shilpee, Mishra, Pradyumna K, Khare, Naveen K, Nair, Naveen K, Dutt, Amit
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447133/
https://ncbi.nlm.nih.gov/pubmed/28580170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.15
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