Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation

Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation that can lead to their oncogenic transformation. Mediator(s) of cell–cell communication that brings about these pro-oncogenic pathologies has not been identified. We show here that cell-free chromatin (cfCh) r...

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Publicado no:Cell Death Discov
Main Authors: Mittra, Indraneel, Samant, Urmila, Sharma, Suvarna, Raghuram, Gorantla V, Saha, Tannistha, Tidke, Pritishkumar, Pancholi, Namrata, Gupta, Deepika, Prasannan, Preeti, Gaikwad, Ashwini, Gardi, Nilesh, Chaubal, Rohan, Upadhyay, Pawan, Pal, Kavita, Rane, Bhagyeshri, Shaikh, Alfina, Salunkhe, Sameer, Dutt, Shilpee, Mishra, Pradyumna K, Khare, Naveen K, Nair, Naveen K, Dutt, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447133/
https://ncbi.nlm.nih.gov/pubmed/28580170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.15
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