Characterization of Acyl-CoA Synthetase Isoforms In Pancreatic Beta Cells: Gene Silencing Shows Participation of ACSL3 and ACSL4 In Insulin Secretion

Long-chain acyl-CoA synthetases (ACSLs) convert fatty acids to fatty acyl-CoAs to regulate various physiologic processes. We characterized the ACSL isoforms in a cell line of homogeneous rat beta cells (INS-1 832/13 cells) and human pancreatic islets. ACSL4 and ACSL3 proteins were present in the bet...

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Publicado no:Arch Biochem Biophys
Main Authors: Ansari, Israr-ul H., Longacre, Melissa J., Stoker, Scott W., Kendrick, Mindy A., O’Neill, Lucas M., Zitur, Laura J., Fernandez, Luis A., Ntambi, James M., MacDonald, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445904/
https://ncbi.nlm.nih.gov/pubmed/28193492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2017.02.001
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