Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article. Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis rates in cells. This pathway is overactivated in brains of patient...

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Publicado en:Brain
Autores principales: Halliday, Mark, Radford, Helois, Zents, Karlijn A. M., Molloy, Collin, Moreno, Julie A., Verity, Nicholas C., Smith, Ewan, Ortori, Catharine A., Barrett, David A., Bushell, Martin, Mallucci, Giovanna R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445255/
https://ncbi.nlm.nih.gov/pubmed/28430857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awx074
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