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A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism
A diastereoselective synthesis of the title compound as a single E diastereomer has been efficiently accomplished by assembling the featured pyrano-indole scaffold of the spiro[cyclohexane-dihydropyrano[3,4-b]-indole]-amine framework through an oxa-Pictet-Spengler reaction, promoted by a cheap and g...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5445067/ https://ncbi.nlm.nih.gov/pubmed/28546566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02502-9 |
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