Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-Diphosphate Inhibitors

Isoprenoid biosynthesis is an important area for anti-infective drug development and one target is IspH, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) reductase, which forms isopentenyl diphosphate and dimethylallyl diphosphate from HMBPP in a 2H(+)/2e(−) reduction. IspH contains a 4Fe-4S...

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Publicat a:Chembiochem
Autors principals: O’Dowd, Bing, Williams, Sarah, Wang, Hongxin, No, Joo Hwan, Rao, Guodong, Wang, Weixue, Andrew McCammon, J., Cramer, Stephen P., Oldfield, Eric
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445010/
https://ncbi.nlm.nih.gov/pubmed/28253432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700052
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