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Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-Diphosphate Inhibitors
Isoprenoid biosynthesis is an important area for anti-infective drug development and one target is IspH, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) reductase, which forms isopentenyl diphosphate and dimethylallyl diphosphate from HMBPP in a 2H(+)/2e(−) reduction. IspH contains a 4Fe-4S...
में बचाया:
| में प्रकाशित: | Chembiochem |
|---|---|
| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5445010/ https://ncbi.nlm.nih.gov/pubmed/28253432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700052 |
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