Loss of KLF4 and Consequential Downregulation of Smad7 Exacerbate Oncogenic TGF-β Signaling in and Promote Progression of Hepatocellular Carcinoma

Hyperactivation of TGF-β signaling pathway is a common feature of hepatocellular carcinoma (HCC) progression. However, the driver factors leading to enhanced TGF-β activity are not well characterized. Here, we explore the mechanisms that loss of Krüppel-like factor 4 (KLF4) exacerbates oncogenic TGF...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Sun, Hongcheng, Peng, Zhihai, Tang, Huamei, Xie, Dacheng, Jia, Zhiliang, Zhong, Lin, Zhao, Senlin, Ma, Zhengyu, Gao, Yong, Zeng, Lixian, Luo, Rongcheng, Xie, Keping
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444978/
https://ncbi.nlm.nih.gov/pubmed/28192402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.447
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